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Also, melanogenic switching was found to be related to tyrosinase activity levels, where high tyrosinase activity produced an excess of dopaquinone resulting in the inactivation of GR and other enzymes essential for pheomelanogenesis [99]

We determined cell viability and cytotoxicity by using tetrazolium reduction assay and Lactate Dehydrogenase (LDH) assay, performed real-time PCR and protein quantification to assess the expression of biomarkers after treating cells with copper peptide (GHK-Cu), copper chloride (CuCl 2 ) and copper acetate (Cu(OAc) 2 )

D., Liu, P